Endocrine Abstracts

Hurthle cell carcinoma (HCC) represents about 5% of differentiated thyroid carcinomas. When Hurtle cell represents more than 75% of cells population, the lesion can be considered a Hurthle cell tumor (HCT); it can be classify as malignant when capsular or vascular invasion is reported or if there is a perithyroid infiltration or distant metastases occur. Aim of this study was to present our own experience on the clinical and pathological features of patients (pts) affected by ...

Introduction: Adult growth hormone deficiency is associated with fatigue, tiredness and myalgias. The same clinical pattern can often be present in oncological patients during chemotherapy and follow up.Aim of the study: To conduct an extensive neuromuscular investigation of patients with breast cancer (BC), treated with taxol, in an attempt to explain their neuromuscular symptoms, eleven pre-menopausal patients with BC underwent a prospective protocol, ...

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...

Background: The management of adjuvant mitotane therapy in patients with adrenocortical carcinoma (ACC) is challenging. Plasma mitotane concentrations>14 mg/l have been associated with efficacy in the treatment of advanced ACC; however, data in the adjuvant setting are mixed. Moreover, there is no consensus on how to assess the optimal exposure to mitotane and all the proposed methods have inherent limitations. We have recently proposed a new method analogous to what is es...

The incidence of Neuroendocrine Neoplasm (NEN) and related carcinoid syndrome (CS) increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics. Unfortunately, there are no studies designed to answer this question in the literature. The present multicentric study was designed to evaluated gender differences, if any, in clinical presentation and outcomes...